Is Trifluridine Tipiracil Tablets (Lonsurf) a chemotherapy drug or a targeted drug?

Trifluridine tipiracil tablets (Lonsurf) is a chemotherapy drug. This is a treatment for bowel cancer that has spread to other parts of the body, stomach cancer that has spread to other parts of the body, and adenocarcinoma of the gastroesophageal junction that has spread to other parts of the body. Trifluridine and tipiracil tablets are composed of two drugs, trifluridine and tipiracil. Trifluridine works by stopping the growth of cancer cells, while tipiracil helps trifluridine work longer by preventing it from being broken down by the body.

After being taken up by cancer cells, tipiracil is integrated intoDNA, interfering with DNA synthesis and inhibiting cell proliferation. Trifluridine/tipiracil demonstrated antitumor activity against KRAS wild-type and mutant human colorectal cancer xenografts in mice. The most common side effects of trifluridine tipiracil when used alone include neutropenia, nausea, fatigue, and anemia; when used in combination with bevacizumab, the most common side effects include neutropenia, fatigue, and nausea.

The original drug of trifluridinetipiracil tablets has been marketed in China under the trade name Langsif, but it has not yet entered the scope of medical insurance. The price per box may be around RMB 6,000, and the price per box of the Hong Kong version may be more than RMB 10,000 (the price may fluctuate due to exchange rates). The Japanese version of trifluridine tipiracil tablets sold overseas may cost around more than 5,000 yuan per box (the price may fluctuate due to exchange rates). There are also cheaper generic versions of trifluridine and tipiracil tablets available overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of each box produced by an Indian pharmaceutical factory may be around more than 1,000 yuan (the price may fluctuate due to exchange rates).