What are the side effects of Talazoparib?

In clinical studies of talazoparib (Talazoparib) for the treatment of BRCA-mutated HER2-negative locally advanced or metastatic breast cancer, the most common (≥20%) adverse reactions (including laboratory Abnormalities) include decreased hemoglobin, neutropenia, lymphopenia, thrombocytopenia, fatigue, increased glucose, increased aspartate aminotransferase, increased alkaline phosphatase, increased alanine aminotransferase, decreased calcium, nausea, headache, vomiting, alopecia, diarrhea, and decreased appetite.

The most common (≥10%) adverse reactions in clinical studies of talazopanib combined with enzalutamide (enzalutamide) for the treatment of HRR gene-mutated metastatic castration-resistant prostate cancer (including laboratory abnormalities), including decreased hemoglobin, neutropenia, lymphopenia, fatigue, thrombocytopenia, decreased calcium, nausea, decreased appetite, decreased sodium, decreased phosphate, fractures, decreased magnesium, dizziness, increased bilirubin, decreased potassium, and dysgeusia. There is no specific treatment in the case of talazopanib overdose, and the symptoms of overdose have not been established. In case of overdose, discontinue talazopanib therapy, consider gastric decontamination, follow general supportive measures, and treat according to symptoms.

The original drug of talazopanib has not yet been marketed in China, so it has not been included in medical insurance. The original drug specification of talazopanib listed overseas is 0.25mg*30 capsules, and the price per box may be around RMB 10,000 (the price may fluctuate due to exchange rate effects), which is relatively expensive. There are also cheaper generics of talazopanib overseas. For example, the price of a box of 1mg*30 pills produced by a Laos pharmaceutical factory may be more than 3,000 yuan (the price may fluctuate due to the exchange rate).