Where to buy Temozolomide

Temozolomide is an oral alkylating agent approved by the U.S. Food and Drug Administration (FDA) for the first-line treatment of glioblastoma multiforme and recurrent anaplastic astrocytoma. Traditional alkylating agents work by creating DNA cross-links, thereby inhibiting DNA and cell replication. Other drugs that work similarly, such as temozolomide, work by methylating DNA, which can also lead to inhibition of DNA and cell replication. All of these drugs work nonspecifically, affecting both cancer cells and normal cells.

Cancer cells divide faster than normal tissue and therefore should be more sensitive to these effects. Temozolomide is an oral prescription drug (although there is an intravenous form) that is given once daily. The half-life of temozolomide is approximately 1.8 hours, and the active half-life of the metabolite (MTIC) is slightly longer. Temozolomide and its metabolites are excreted via the kidneys. Nausea and vomiting are common side effects, usually mild to moderate. Seizures and thrombocytopenia occurred in less than 7% of patients.

The original drug of temozolomide has been launched in China and has entered the scope of Class B medical insurance. Common specificationsThe price of 100mg*1 pill*5 bags per box may be around 2,000 yuan. This drug may be sold in domestic hospitals or pharmacies, and patients can choose by themselves. The price of generic temozolomide drugs marketed overseas is relatively low, and its pharmaceutical ingredients are basically the same as those of the original temozolomide drug. For example, the price of a box of 100mg*5 produced by a Bangladeshi pharmaceutical factory may be around a few hundred yuan (the price may fluctuate due to exchange rates).