The difference between domestic and imported Temozolomide

Temozolomide (Temozolomide) has domestically produced drugs and imported drugs on the market. The difference lies in different manufacturers, different production specifications, and drug prices. However, the ingredients of domestic drugs and imported drugs may be basically the same. Temozolomide is an alkylating agent used to treat newly diagnosed glioblastoma in adults, accompanied by radiotherapy, and then as maintenance therapy. It is also used for the adjuvant treatment of newly diagnosed anaplastic astrocytoma in adults and the treatment of refractory anaplastic astrocytoma in adults.

Prior to dosing, temozolomide needs to be discontinued until the patient's absolute neutrophil count (ANC) is 1.5x109/L or higher and the platelet count is 100x109g/L or higher. For concomitant radiation therapy, perform a complete blood count before starting treatment and weekly during treatment. For 28-day treatment cycles, obtain a complete blood count before treatment on Days 1 and 22 of each cycle. If ANC is less than 1.5x109/L and platelet count is less than 100x109/L, perform a complete blood count weekly until recovery. For patients receiving temozolomide concurrently with focal radiation therapy, a complete blood count should be obtained weekly as clinically indicated.

Temozolomide’s original drug and imported drugs have entered the scope of Class B medical insurance. The common specifications of imported drugsThe price of 100mg*1 pill*5 bags per box may be around 2,000 RMB. The common specifications of domestic drugs, 100mg*5 pills, may be priced at several hundred RMB per box. The prices of generic temozolomide drugs marketed overseas are relatively low, and their drug ingredients are basically the same as those of the original temozolomide drug. For example, the price of a box of 100mg*5 produced by a Bangladeshi pharmaceutical factory may be around a few hundred yuan (the price may fluctuate due to the exchange rate). For more drug information and specific prices, please consult a medical consultant.