Temozolomide concurrent chemoradiotherapy regimen

Survival rates for glioblastoma (GBM) patients are poor but improve with tumor resection and radiation therapy (RT). Concomitant chemotherapy with temozolomide during radiation therapy improves survival in younger patients with glioblastoma, but the benefit in older patients is unclear. The specific plan will be adjusted according to the patient's specific situation, including the stage of the disease, the patient's age, physical condition and tolerance and other factors.

In general, the usual dose of modozolomide is taken orally once daily for 42 days. Radiation therapy, on the other hand, is usually given using standard fractions, usually once a day, five times a week, usually for 6 weeks. In concurrent chemoradiotherapy regimens, modozolomide is usually administered at the same time as the start of radiotherapy, that is, starting one week before the start of radiotherapy and continuing for a period of time after the end of radiotherapy for 6-12 months or until treatment intolerance, progression, or death. The specific dosage and duration of medication need to be adjusted by the doctor according to the patient's condition. During treatment with concurrent chemoradiotherapy, patients need to closely monitor side effects and report them to their doctors in a timely manner. Common side effects include nausea, vomiting, fatigue, leukopenia, etc. Doctors will handle and adjust accordingly according to the patient's specific situation.

The original drug temozolomide has been launched in China and has entered the scope of Class B medical insurance. Common specificationsThe price of 100mg*1 tablet*5 bags per box may be around 2,000 yuan. The generic drugs of temozolomide marketed overseas are relatively low-priced, and their drug ingredients are basically the same as those of the original drug of temozolomide. For example, the price of a box of 100mg*5 produced by a Bangladeshi pharmaceutical factory may be around a few hundred yuan (the price may fluctuate due to exchange rates).