Is oral temozolomide as effective as injecting it?

For clinical use, Temozolomide, available under the brand name Temodar, can be administered orally in concentrations of 5, 20, 100, 140, 180 and 250 mg, but it is also available as a solution for intravenous administration (at a concentration of 100 mg/ml). Temozolomide can be rapidly and completely absorbed in the gastrointestinal tract and is stable at both acidic and neutral pH. Therefore, temozolomide can be administered orally and intravenously with a mean Tmax of 1 hour.

After a single oral doseAfter a dose of 150 mg/m2, the Cmax values of temozolomide and its active MTIC metabolite are 7.5 μg/mL and 282 ng/mL respectively, and the AUC values are 23.4 μg*hr/mL and 864 ng/mL respectively. Similarly, after a single intravenous infusion of 150 mg/m2 for 90 minutes, the Cmax values u200bu200bof temozololide and its active MTIC metabolite were 7.3 μg/mL and 276 ng/mL, respectively, and the AUC values u200bu200bwere 24.6 μg*hr/mL and 891 ng/mL, respectively. Temozolomide kinetics are linear over the range of 75-250 mg/m2/day. MedianTmax is 1 hour.

The original drug temozolomide has been launched in China and has entered the scope of Class B medical insurance. Common specificationsThe price of 100mg*1 tablet*5 bags per box may be around 2,000 yuan. The generic drugs of temozolomide marketed overseas are relatively low-priced, and their drug ingredients are basically the same as those of the original drug of temozolomide. For example, the price of a box of 100mg*5 produced by a Bangladeshi pharmaceutical factory may be around a few hundred yuan (the price may fluctuate due to exchange rates).