How to administer Trastuzumab injection (subcutaneous injection) (Herceptin Hylecta)

Before patients are treated with trastuzumab injection (subcutaneous injection ) (Herceptin Hylecta) , doctors will select patients based on HER2 protein overexpression or HER2 gene amplification in tumor specimens. Assessment of HER2 protein overexpression and HER2 gene amplification should be performed by a laboratory with proven capabilities using an FDA-approved breast cancer-specific test. The recommended dose of trastuzumab injection (subcutaneous injection) is 600 mg/10,000 units (600 mg trastuzumab and 10,000 units of hyaluronidase), subcutaneously injected once every three weeks, about 2-5 minutes each time. No loading dose is required, and no dose adjustments are required based on patient weight or different concomitant chemotherapy regimens.

Patients with adjuvant breast cancer should receive trastuzumab injection (subcutaneous injection) treatment52 weeks or until disease recurrence, whichever occurs first; it is not recommended to extend the treatment time for adjuvant breast cancer to more than one year. Patients with metastatic breast cancer (MBC) should receive trastuzumab injection (subcutaneous injection) until the disease progresses. If a dose is missed, it is recommended to take the next dose of 600 mg/10,000 units as soon as possible, and the interval between subsequent doses should not be less than three weeks. Trastuzumab injection (subcutaneous) is for subcutaneous injection only and has different dosage and administration instructions than intravenous trastuzumab products.

It is understood that the original drug of trastuzumab injection (subcutaneous injection) has been launched in China, but the specific price and other relevant information are not yet clear. Since the drug has been on the market for a short time, it has not been included in the scope of medical insurance. At present, there are no generic drugs of Trastuzumab injection (subcutaneous injection) produced and marketed. For more information and specific prices of Trastuzumab injection (subcutaneous injection), please consult a medical consultant.