How long does a course of selumetinib treatment last?

Selumetinib is an oral, selective mitogen-activated protein kinase (MEK) 1 and 2 inhibitor. SelumetinibblocksMEK activity and inhibits the growth of cell lines with activated RAF-MEK-ERK pathway, resulting in inhibition of cell proliferation and PN growth. Selumetinib is available in 10 mg or 25 mg oral capsules. The recommended dose of selumetinib is 25 mg/m2 based on body surface area (BSA) twice daily.

Although the exact duration of treatment with selumetinib has not yet been determined, experts suggest that, similar to the SPRINT phase trial, in clinical practice, patients will continue treatment until disease progression or toxicity occurs. It is expected that the initial treatment authorization period for patients with selumetinib should be 18 months. Selumetinib should be discontinued in patients who do not respond (i.e., tumor growth, lack of stabilization, or symptom improvement), or who experience uncontrollable serious adverse events (AEs). The need for surgery to further eliminate the tumor may indicate that the treatment is not working and should be discontinued.

SelumetinibThe original drug has been launched in China, but it has not yet entered the scope of medical insurance. SpecificationThe price of 10mg*60 tablets per box may be more than 20,000 yuan, which is relatively expensive. SelumetinibOriginal drug marketed overseas, the price of 10mg*60 pills per box may be more than 50,000 yuan, and the price of 25mg*60 pills per box may be 1 More than RMB 00,000 (the price may fluctuate due to the exchange rate). The ingredients of the original version of selumetinib sold at home and abroad are basically the same. There is currently no generic version of selumetinib on the market. For more drug information and specific prices, please consult Yaode Medical Consultants.