What are the side effects of Sacituzumab govitecan?

About gosatuzumab govitecan)Among the four studies (IMMU-132-01, ASCENT, TROPiCS-02 and TROPHY), the most common (≥25%) adverse reactions ( including laboratory abnormalities), including decreased white blood cell count, decreased neutrophil count, decreased hemoglobin, diarrhea, nausea, decreased lymphocyte count, fatigue, hair loss, constipation, increased glucose, decreased albumin, vomiting, decreased appetite, decreased creatinine clearance, increased alkaline phosphatase, decreased magnesium levels, decreased potassium levels, and decreased sodium levels.

Warnings and precautions such as neutropenia, diarrhea, allergic and infusion-related reactions, nausea and vomiting, reduced uridine diphosphate-glucuronosyltransferase activity, and embryo-fetal toxicity have also emerged in clinical studies of gosatuzumab. According to its prescribing information, gosatuzumab is contraindicated in patients who have had a severe allergic reaction to sacituzumab govitecan. Do not use gosatuzumab as a substitute for or together with other medicines containing irinotecan or its active metabolite SN-38.

Gosatuzumab The original drug has been launched in China, but it has not yet been included in the medical insurance. The price of a 100mg bottle may be around 10,000 yuan, which is relatively expensive. Gosatuzumab Original drug marketed overseas has three versions: European version, American version, and Singapore version. SpecificationsThe price of each 100 mg bottle may be around RMB 10,000-35,000 (the price may fluctuate due to exchange rates). The ingredients of gosatuzumab sold domestically and abroad are basically the same. There is currently no generic version of gosatuzumab available on the market. For specific prices and drug information, please consult your medical consultant.