How much does a box of Rucaparib cost?

Rucaparib (Rucaparib) is indicated for the maintenance treatment of adults with platinum-sensitive recurrent high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who have responded (completely or partially) to platinum-based chemotherapy. Rucaparib is also used to treat prostate cancer in the United States. Rucaparib inhibits the contraction of isolated vascular smooth muscle, including smooth muscle from tumors of cancer patients, and it also reduces the migration of some cancer and normal cells in culture. As a PARP inhibitor, rucaparib is expected to be more effective against the 9% of pancreatic cancers with BRCA mutations (BRCA1 or BRCA2).

Rucapanib is an anticancer drug that has cytotoxic effects on cancer cells. It works by inhibiting poly(ADP-ribose) polymerase (PARP), an enzyme that plays a role in DNA repair. Rucaparib inhibits PARP-1, PARP-2 and PARP-3. It also interacts with PARP-4, PARP-10, PARP-12, PARP-15 and PARP-16, but to a lesser extent. In mice, rucaparib accumulated and remained in tumors, inhibiting PARP enzymes for up to 7 days. Rucaparib reduced tumor growth in tumor cell lines lacking BRCA1/2 and other DNA repair genes.

The original drug Rucapani has not yet been marketed in the country, so it has not entered the medical insurance coverage standards. The European version of rucapani original drug, specifications300mg*60 tablets sold overseas may cost more than 20,000 yuan per box (the price may fluctuate due to exchange rate effects), which is relatively expensive. There are also cheap generic rucapani drugs available overseas, and their pharmaceutical ingredients are basically the same as those of the original rucapani drug. For example, in India, the price of BDR pharmaceutical specifications of 300mg*60 tablets per box may be more than 6,000 yuan (the price may fluctuate due to exchange rate effects).