What are the side effects of taking Deferasirox dispersible tablets for a long time?

Deferasirox dispersible tablets (Deferasirox) is a drug used to treat iron overload caused by multiple blood transfusions. Its main function is to bind excess free iron in the body and promote its excretion from the body. Although deferasirox is excellent at reducing iron overload, long-term use of any drug can be associated with some potential risks and possible sequelae.

The following are some potential problems that may be associated with long-term use of deferasirox dispersible tablets:

1. Effects on liver and kidney function: Long-term use of deferasirox may have certain effects on liver and kidney function. This is because the excretion of drugs is mainly completed through these two organs. Regular liver and kidney function tests are necessary to ensure the health of these organs.

2. Gastrointestinal reactions: The use of deferasirox may be associated with gastrointestinal discomfort, including nausea, vomiting, diarrhea, etc. These reactions may lessen over time in some patients, but for some it may be a long-term problem.

3. Hearing problems: Some studies suggest that deferasirox use may be associated with hearing problems, especially at high doses or with long-term use. Therefore, patients may need to undergo regular hearing monitoring.

4. Retinopathy: There are reports that the use of deferasirox may be associated with retinopathy, which may have adverse effects on vision. Therefore, eye examinations may be recommended during treatment.

5. Other discomfort reactions: Long-term use of deferasirox may also be associated with other discomfort reactions, including headache, rash, muscle and joint pain, etc. There is considerable variability in these responses between individuals, and some people may be more tolerant to the drug.

6. Drug tolerance: Long-term use of deferasirox may lead to drug tolerance problems, that is, the drug may gradually lose its original effectiveness during treatment. In this case, your doctor may need to adjust the dose or choose another treatment.

7. Bone problems: Some studies suggest that iron overload and deferasirox use may be associated with bone problems, including reduced bone density. Therefore, bone density testing and monitoring of bone health may become more important with long-term use.

8. Immune system effects: Long-term use of deferasirox may have certain effects on the immune system, although the specific effects are still under study.

9. Other potential problems: Since deferasirox is a relatively new drug, some potential problems with long-term use are still being studied, including its impact on fertility, cancer risk, etc.

During long-term use of deferasirox dispersible tablets, doctors will closely monitor the patient's various physiological indicators and adjust the treatment plan as necessary. Patients should also actively communicate with their doctors and undergo regular examinations so that any possible sequelae or discomfort can be discovered and dealt with in a timely manner. Treatment plans should be individualized and tailored based on the patient's overall condition and response to treatment.

Dedeferasirox dispersible tablets have been launched in China and have been included in medical insurance. Patients can purchase them domestically. The price of domestic specifications125mg*28 tablets is around 600 to 700. For specific prices and medical insurance reimbursement, please consult the local hospital pharmacy. There are original and generic deferasirox dispersible tablets in foreign countries. The original drug is mainly the Swiss Novartis original drug, and the price of 400mg*30 tablets is around 400 to 500; the generic drugs are mainly Indian generic drugs, and the specification of 400mg*30 tablets is about 300 to 400, and the ingredients of the original drug and generic drugs are basically the same.