Chinese instructions for Deferasirox dispersible tablets

1. Indications

Delasirox dispersible tablets are mainly used to treat symptoms of iron overload in the body and are suitable for the following conditions:

1.Transfusion-dependent diseases: Mainly include thalassemia patients treated with long-term blood transfusions and β-thalassemia patients.

2.Non-transfusion-dependent diseases: Applicable to iron overload in the body caused by non-transfusion-dependent diseases, such as congenital non-iron deficiency anemia, etc.

2. Mechanism of action

Deferasirox dispersible tablets are an iron chelator that combines with free iron ions to form a stable chelate, reducing the damage of free iron ions to body tissues. Its mechanism of action mainly includes:

1.Iron chelation: Delasirox combines with free iron to form a soluble chelate, which increases the excretion of iron in the body.

2.Reducing iron content in the body: By increasing urinary iron excretion and reducing intestinal iron absorption, deferasirox can effectively reduce the total iron content in the body.

3. Pharmacology

The pharmacological characteristics of deferasirox dispersible tablets include:

1.Absorption: The drug is rapidly absorbed after oral administration and has high bioavailability.

2.Distribution: Delasirox is mainly distributed in the liver, kidneys and intestinal tissues, and is weakly bound to proteins.

3.Metabolism: This drug is mainly metabolized by the liver to form major metabolites.

4.Excretion: Delasirox and its metabolites are mainly excreted through bile, and a small part is excreted through urine.

4. Dosage and usage

Patients should receive detailed medication instructions according to their doctor's recommendations before using deferasirox dispersible tablets. General advice:

1.Dose: The initial dose and maintenance dose need to be determined based on the patient's weight and degree of iron overload.

2.Usage: Usually taken orally on an empty stomach, avoid taking it at the same time with iron-containing foods and medications to ensure optimal absorption.

3.Adjust dosage: Doctors will regularly check the patient's iron content and adjust the dosage of deferasirox as needed.

5. Side Effects

Some side effects may occur during use of deferasirox dispersible tablets, common ones include but are not limited to:

1.Digestive system: Nausea, vomiting, diarrhea, etc.

2.Liver function: Elevated liver enzymes.

3.Kidney function: Abnormal kidney function.

4.Skin reactions: Skin rash, itching, etc.

If patients experience serious discomfort during use, they should seek medical attention immediately.

6. Warnings and Precautions

1. Liver function monitoring: Liver function should be monitored regularly during treatment. If there is any abnormality, the medication regimen should be adjusted in a timely manner.

2. Renal function monitoring: For patients with impaired renal function, it should be used with caution and renal function should be closely monitored.

3. Use with caution in pregnant women: Use with caution in pregnant women and decide whether to use it after clinical evaluation of potential risks and benefits.

7. Contraindications

Deferasirox dispersible tablets are contraindicated in the following situations:

1.Allergic reaction: Those who are allergic to any ingredient in the drug.

2.Pregnant women: It may have adverse effects on the fetus, especially in the first trimester.

8. Drug interactions

1. Antifungal drugs: Delasirox dispersible tablets may interact with certain antifungal drugs and their simultaneous use should be avoided.

2. Iron preparations: Use in combination with other iron preparations may increase toxicity and should be used with caution.

9. Medication for Special Populations

1.Medications for children: Medications for children need to be determined according to weight and age, and should be used under the guidance of a doctor.

2. Elderly patients: For elderly patients, the dose needs to be adjusted based on renal function and overall health.

10. Listing and price situation:

Dedeferasirox dispersible tablets have been launched in China and have been included in medical insurance. Patients can purchase them domestically. The price of domestic specifications125mg*28 tablets is around 600 to 700. For specific prices and medical insurance reimbursement, please consult the local hospital pharmacy. There are original and generic deferasirox dispersible tablets in foreign countries. The original drug is mainly the Swiss Novartis original drug, and the price of 400mg*30 tablets is around 400 to 500; the generic drugs are mainly Indian generic drugs, and the specification of 400mg*30 tablets is about 300 to 400, and the ingredients of the original drug and generic drugs are basically the same.