The functions and efficacy of Ruxolitinib cream

Ruxolitinib cream is a topical preparation of ruxolitinib, which is a potent and selective inhibitor of Janus kinase (JAK) 1 and JAK2. Targeting these kinases has been associated with therapeutic benefits in patients with atopic dermatitis (AD) and non-segmental vitiligo. Ruxolitinib cream was well tolerated in the patient population of clinical studies; its safety profile was similar to that of vehicle cream in the short term, and the types of adverse events that emerged with treatment were typical of the longer vehicle-controlled period.

In two identically designed, multinational, Phase III studies in patients ≥12 years of age with mild-to-moderate atopic dermatitis, ruxolitinib cream improved disease severity, pruritus, and sleep disturbance by 1.5% compared with vehicle cream when used twice daily for 8 weeks. Over the next 44 weeks, disease severity is controlled when applied as needed to active lesions. in parent In the TRuE-V trial, which evaluated time to recurrence per Vitiligo Area Severity Index (F-VASI) in adolescent and adult patients with non-segmental vitiligo, approximately 30% of patients who received ruxolitinib cream Patients achieved F-VASI90 at week 52, and many patients who first started using ruxolitinib cream achieved a significant degree of facial pigmentation and were able to maintain this benefit up to 1 year after discontinuation of treatment. Among patients who dropped out of treatment, relapses generally resolved, and there were no serious adverse events after 2 years of ruxolitinib cream.

The original drug of ruxolitinib cream has not yet been marketed in China, so it cannot be included in medical insurance. The price of ruxolitinib cream Original drug, specificationsinn 1.5%*60g, which is marketed overseas, is around RMB 20,000 per tube (the price may fluctuate due to the exchange rate), which is relatively expensive. The price of generic ruxolitinib cream marketed overseas is relatively cheap, and its pharmaceutical ingredients are basically the same as those of the original drug. The price of the specificationinn 1.5%*30g produced by a Bangladesh pharmaceutical factory is around 600 yuan per tube (the price may fluctuate due to exchange rate effects).