How to take Pitolisant-wakix

Pitolisant Tablets (Pitolisant) - The recommended dosage range of wakix is 17.8mg to 35.6mg, taken orally once daily after waking up in the morning. Start taking 8.9 mg once daily (two 4.45 mg tablets) in the first week; increase the dose to 17.8 mg once daily (one 17.8 mg tablet) in the second week; and increase to the maximum recommended dose of 35.6 mg once daily (two 17.8 mg tablets) in the third week. Dosage may be adjusted based on tolerance. If a dose is missed, the patient should take the next dose upon waking the next morning. Some patients may take up to 8 weeks to achieve clinical response.

For patients with moderate hepatic impairment, the starting dose of tilolixen tablets is 8.9 mg once daily and is increased to a maximum dose of 17.8 mg once daily after 14 days. Tilolixen tablets are contraindicated in patients with severe hepatic impairment. For patients with moderate (eGFR 30-59 mL/min/1.73m2) or severe (eGFR 15-29 mL/min/1.73m2) renal impairment, the initial dose of tilolixen tablets is 8.9 mg once daily and is increased to a maximum dose of 17.8 mg once daily after 7 days. Tilolixen tablets are not recommended for patients with end-stage renal disease (ESRD) (eGFR <15mL/min/1.73m2).

Tilorisen tablets have been marketed in the country, but have not yet been included in medical insurance. The price of each box of the original version of tilorisen tablets marketed overseas may be over more than RMB 4,000 (the price may fluctuate due to exchange rates). Currently, there are no generic versions of tilorisen tablets produced and marketed overseas.