What are the side effects of Fam-trastuzumab deruxtecan-nxki?

In Fam-trastuzumab (Fam-trastuzumab deruxtecan-nxki)In clinical studies for the treatment of breast cancer, non-small cell lung cancer, and gastric cancer, the most common (≥20%) adverse reactions (including laboratory abnormalities) are nausea, reduced white blood cell count, and reduced hemoglobin , decreased neutrophil count, decreased lymphocyte count, fatigue, decreased platelet count, increased aspartate aminotransferase, vomiting, increased alanine aminotransferase, alopecia, increased blood alkaline phosphatase, constipation, musculoskeletal pain, decreased appetite, diarrhea, hypokalemia, increased blood bilirubin, and fever.

Interstitial lung disease (ILD) and pneumonia, including fatal cases, have been reported with trastuzumab. Monitor and promptly investigate signs and symptoms, including cough, difficulty breathing, fever, and other new or worsening respiratory symptoms. Permanently discontinue trastuzumab in all patients with grade 2 or higher interstitial lung disease/pneumonitis. Inform patients of the risks and the need to report symptoms immediately. Exposure to interstitial lung disease during pregnancy can cause harm to the embryo-fetus. Inform patients of these risks and the need for effective contraception.

Trastuzumab is a new type of injectable anti-cancer drug. Due to its short time on the market, it has not yet entered the scope of medical insurance. It is a strictly controlled drug and its purchase is restricted. The price of Trastuzumab original drug specifications100mg per box sold in Hong Kong may be more than RMB 10,000 (the price may fluctuate due to the exchange rate). There are currently no generics of Trastuzumab on the market. For more specific prices and drug information, please consult a medical consultant.