The role and efficacy of Fam-trastuzumab deruxtecan-nxki

Fam-trastuzumab deruxtecan-nxki is effective in patients with HER2-positive breast cancer who are receiving one or more HER2-targeted therapies. Additionally, it was effective in treating HER2-low breast cancer in patients who had previously received another cancer drug. The side effects of trastuzumab are considered manageable and similar to those of other trastuzumab-containing medicines, although the risk of lung disease may be higher with trastuzumab. These side effects, including those affecting the lungs, are mostly reversible and can be managed by changing the dose and closely monitoring the patient.

Trastuzumab is a HER2-directed antibody-drug conjugate, which is a humanized anti-HER2 IgG1. The small molecule DXd is a topoisomerase I inhibitor linked to an antibody via a cleavable linker. After binding to HER2 on tumor cells, trastuzumab undergoes internalization and intracellular linker cleavage by lysosomal enzymes. After release, membrane-permeable DXd causes DNA damage and apoptotic cell death. Treatment with trastuzumab also showed benefit in a group of patients with gastric and gastroesophageal cancer who had previously received therapies including trastuzumab and had few treatment options. As such, it is considered to address an unmet medical need in these patients, although the lack of a control group in the primary study limits assessment of the benefits and risks associated with its use.

Trastuzumab is a new type of injectable anti-cancer drug. The original drug has been launched in China, but it has not yet entered the scope of medical insurance. It is a strictly controlled drug. The domestic price is not yet clear, and its purchase method is difficult. The Hong Kong version of TrastuzumabSpecifications100mg may cost more than 10,000 yuan per box, and the Hong Kong original versionTrastuzumabOriginal drug specificationsThe price of 100mg per box may be around 15,000 yuan (the price may fluctuate due to exchange rate effects). The drug ingredients of the two are basically the same. There is currently no generic drug of Trastuzumab produced and launched. For more specific prices and drug information, please consult the medical consultant of the drug.