Is it okay to take 12 injections of Ado-trastuzumab emtansine?

Ado-trastuzumab emtansine is a prescription drug that is usually infused intravenously every 3 weeks (21-day cycle) and needs to be treated according to the prescription information until intolerable toxicity occurs. Patients with early-stage breast cancer may receive a total of 14 cycles of treatment. It can be seen that 12 injections of trastuzumab may need to be determined according to the patient's own situation and cannot be chosen by himself.

Since2013, trastuzumab has been approved by the FDA as a monotherapy for the treatment of advanced metastatic HER2-positive breast cancer. Trastuzumab has also shown improved outcomes as an adjuvant treatment for patients with residual invasive breast cancer after neoadjuvant therapy. On May 3, 2019, the FDA approved trastuzumab for the adjuvant treatment of HER2-positive breast cancer in patients who remain diseased after neoadjuvant taxane-based chemotherapy and trastuzumab-based therapy. In clinical trials, an overdose of trastuzumab at approximately twice the recommended dose was reported, resulting in grade 2 thrombocytopenia (resolving after 4 days) and one death. In the fatal case, the patient mistakenly received 6 mg/kg of trastuzumab and died approximately 3 weeks after the overdose; the cause of death and causal relationship to trastuzumab have not been determined.

EnmetratrastuzumabThe monoclonal antigenic drug has been launched in China and has entered the scope of medical insurance. Only eligible patients can be reimbursed. SpecificationsThe price of 100mg per box may be around 20,000 yuan. This drug is a strictly controlled drug. Listed overseas Enmei Trastuzumab The single-unit generic drug has Turkish and European versions, with specifications The price of each box of 100 mg may be around 3,000-8,000 yuan (the price may fluctuate due to the exchange rate). The ingredients of the originator drugs sold domestically and abroad are basically the same, and there are currently no generic versions of Enmei Trastuzumab produced and launched.