Do I need to take chemotherapy drugs when taking Ado-trastuzumab emtansine?

The anti-tumor mechanism of Ado-trastuzumab emtansine is dual. First, it retains the anti-tumor mechanisms of the humanized monoclonal antibody trastuzumab: inhibition of HER2 signaling, inhibition of HER2 extracellular domain shedding, and mediation of antibody-dependent cell-mediated cytotoxicity (ADCC). Trastuzumab is T-DM1. Existing clinical data show that compared with traditional chemotherapy, antibody-directed chemotherapy has higher efficacy and safety.

Trials conducted to date have demonstrated its value in the setting of trastuzumab-pretreated HER2+ metastatic disease, and while this therapy is very promising, new and acquired resistance to trastuzumab will emerge. In some cases, trastuzumab may be used as a standalone treatment without the need to combine it with chemotherapy drugs. This usually applies to patients who are not candidates for chemotherapy or who have already been treated with chemotherapy. However, in other cases, trastuzumab may need to be used in combination with chemotherapy drugs to achieve better therapeutic effects.

EnmetratrastuzumabThe monoclonal antigenic drug has been launched in China under the trade name Hercelium and is covered by medical insurance. Only eligible patients can be reimbursed. SpecificationsThe price per box of 100 mg may be around 20,000 yuan. This drug is a strictly controlled drug. Listed overseas Enmei Trastuzumab The single-unit generic drug has Turkish and European versions, with specifications The price of each box of 100 mg may be around 3,000-8,000 yuan (the price may fluctuate due to the exchange rate). The ingredients of the originator drugs sold domestically and abroad are basically the same, and there are currently no generic versions of Enmei Trastuzumab produced and launched.