How long does a course of Enasidenib last?

A course of treatment with Enasidenib is usually 28 days. During treatment, patients took the drug ensidipine once a day for 28 days. However, the specific length of treatment may vary depending on the patient's condition and the doctor's recommendations. Pharmacokinetics are not affected by age, race, mild hepatic impairment, renal impairment, sex, body weight, or body surface area.

The pharmacokinetics of ensidipine support convenient once-daily dosing of 100 mg in subjects with relapsed and refractory acute myeloid leukemia (AML). The absolute bioavailability after a 100 mg oral dose is approximately 57%, with a median time to Cmax of 4 hours. Food intake has no significant effect on absorption. EnsidipineThe plasma protein binding rate is 98.5%, the average distribution volume is 55.8 L, and the terminal half-life is 137 hours, reaching a steady state on the 29th day of treatment. If ensidipine is being held due to toxicity, clinicians should be aware that ensidipine will persist in the body for a long time after the last dose. Eliminated through feces and urine.

Ensiidi plain investigational medicine is not currently on the market in the country, nor is it covered by medical insurance. The price of ensidipine plain medicine when it is launched overseas is very high, and the price of each box may be around 30,000 yuan (the price may fluctuate due to the exchange rate). Currently, there are cheaper generic encidipine drugs produced by other pharmaceutical companies overseas. For example, the price of Specification50mg*60 tablets produced by a Bangladesh pharmaceutical factory may be around 4,000 yuan per box (the price may fluctuate due to exchange rates). Its drug ingredients are basically the same as those of the original encidipine generic drug.