The role and efficacy of Avatrombopag

Avatrombopag (Avatrombopag) is a thrombopoietin receptor (TPOR; MPL) agonist with possible megakaryopoiesis-stimulating activity. After administration, avatrombopagbinds to and stimulates the platelet thrombopoietin receptor (TPOR), which causes megakaryocytes to proliferate and differentiate from myeloid progenitor cells. This process increases platelet production and may help prevent chemotherapy-induced thrombocytopenia (CIT). TPOR is classified as a member of the cytokine receptor and hematopoietic receptor superfamilies.

Administration of avatrombopag to adult patients may result in dose- and exposure-dependent increases in platelet counts. The onset of platelet count increases was observed within 3 to 5 days after initiation of treatment, reaching a peak after 10 to 13 days. After treatment, platelet counts gradually decreased and returned to values u200bu200bclose to baseline. At exposures similar to those at the 40 mg and 60 mg doses, avatropopag did not prolong the QT interval to any clinically relevant extent. Based on analysis of pooled clinical trial data in patients with chronic liver disease, the highest recommended therapeutic dosing regimen is not expected to produce a mean QTc prolonging effect >20 ms. In both indications, avatrombopag therefore provides a useful alternative to other available treatments.

The original drug of avatrombopag has been launched in China and has entered the scope of Class B medical insurance, but it is only reimbursed for eligible patients. The price of a common specification of 20mg*15 tablets may be more than 7,000 yuan per box, while the original drug of avatrombopag marketed overseas is even more expensive. It is understood that there are generic drugs of avatrombopag available overseas, and their pharmaceutical ingredients are basically the same as those of the original drug. For example, the price of a box of 20mg*30 tablets in Laos pharmaceutical production specifications may be around RMB 1,000 (the price may fluctuate due to exchange rates).