How long does it take to stop taking Avatrombopag?

Avatrombopag (Avatrombopag) is an oral thrombopoietin receptor agonist (TPO-RA) taken with food. In the pivotal Phase 3 study, most patients taking avatrombopag achieved platelet counts of at least 50,000/L on day 8 of treatment, which was superior to placebo in maintaining platelet counts within the target range over the 6-month treatment period. Two Phase 2 clinical trials of ITP and two Phase 3 trials of the treatment of thrombocytopenia in patients with chronic liver disease provide additional supporting efficacy data for sNDA in chronic immune thrombocytopenia.

Before starting avatrombopag, patients should talk to their doctor about the correct dosage and duration of treatment. Typically, the duration of treatment depends on the severity of the condition and response to medications. Typically, treatment with avatrombopag lasts from several weeks to several months. Doctors may gradually adjust the dose to achieve optimal results and evaluate efficacy based on platelet count results. Your doctor may recommend tapering off the medication when your target platelet count is reached or when your doctor deems it appropriate.

The original drug of avatrombopag has been launched in China and has entered the scope of Class B medical insurance, but it is only reimbursed for eligible patients. The price of a common specification of 20mg*15 tablets may be more than 7,000 yuan per box, while the original drug of avatrombopag marketed overseas is even more expensive. It is understood that there are generic drugs of avatrombopag available overseas, and their pharmaceutical ingredients are basically the same as those of the original drug. For example, the price of a box of 20mg*30 tablets in Laos pharmaceutical production specifications may be around RMB 1,000 (the price may fluctuate due to exchange rates).