What are the side effects of Erdafitinib?

In clinical studies of Erdafitinib (Erdafitinib), the most common adverse reactions (ARs) are stomatitis, fatigue, diarrhea, dry mouth, nail abnormalities, decreased appetite, dysgeusia, dry skin, Dry eye, alopecia, palmar-plantar dysesthesia syndrome, constipation, abdominal pain, nausea, and musculoskeletal pain; laboratory abnormalities include increased phosphate, increased creatinine, increased alanine aminotransferase, increased alkaline phosphatase, decreased sodium, decreased albumin, decreased hemoglobin, increased aspartate aminotransferase, decreased magnesium, decreased phosphate, and increased calcium.

The most common grade 3 or higher adverse reactions (>1%) with erdafitinib were stomatitis, nail dystrophy, palmar-plantar dysesthesia syndrome, paronychia, nail abnormalities, keratitis, and hyperphosphatemia. Erdafitinib may also cause serious eye problems, including inflamed eyes, inflamed cornea (the front part of the eye), and retinal disorders inside the eye. Patients are advised to have intermittent eye exams and to tell their healthcare professional immediately if they experience blurred vision, vision loss, or other visual changes.

The original version of erdafitinib has not yet been launched in China, so it cannot be covered by medical insurance. The original version of erdafitinib currently sold in Hong Kong may cost more than 20,000 yuan per box of specifications 4mg*14 tablets (the price may fluctuate due to exchange rates). Cheaper erdafitinib generic drugs produced by other pharmaceutical factories are also sold overseas. The pharmaceutical ingredients are basically the same as those of the original drug. For example, the price of 4mg*60 tablets produced by a Bangladeshi pharmaceutical factory may be more than 3,000 yuan per box (the price may fluctuate due to exchange rates).