Chinese instructions for Ivosidenib

1. Indications:

Ivonib is mainly suitable for patients with acute myeloid leukemia (AML) who express IDH1 gene mutations. The drug is used as < span>IDH1Inhibitors slow down or prevent the growth and proliferation of leukemia cells caused by this mutation by targeting the abnormally activated IDH1 enzyme.

2. Mechanism of action:

Avosidenib blocks the metabolic pathway in leukemia cells by inhibiting the abnormal activation of IDH1 enzyme and promotes cell apoptosis and stagnation, thereby achieving the effect of treating AML.

3. Pharmacology:

Avosidenib is metabolized into active metabolites in the body, mainly through liver enzymesCYP3A4, and is eventually eliminated from the body. The metabolism and excretion of drugs in the body may be affected by individual differences.

4. Dosage and usage:

The specific dosage and usage should be determined according to the specific situation of the patient, and should be adjusted by a professional doctor based on the patient's age, physical condition, IDH1 gene mutation and other factors. Patients should use the medicine accurately according to the doctor's recommendations and should not change the dosage or stop taking the medicine on their own.

5. Side effects:

Using ivonib may cause a series of side effects, including but not limited to nausea, fatigue, shortness of breath, etc. Patients should pay close attention to their physical condition during medication and inform their doctor promptly if they experience any discomfort or serious side effects.

6. Warnings and Precautions:

Liver function monitoring: Patients' liver function should be monitored regularly during use, especially during the first few months of treatment.

Bleeding risk: There is a risk of bleeding, especially when used in combination with other anticoagulant drugs, and close monitoring is required.

Risk to fetal development: Use with caution by pregnant women as it may have adverse effects on the fetus.

7. Contraindications:

Contraindicated in patients who are allergic to ivonib or any component of the drug.

8. Drug interactions:

While using ivosidenib, patients should inform their doctor about all medications they are taking, including over-the-counter medications and supplements, to avoid potential drug interactions.

9. Drugs for special groups:

Pregnant and lactating women: Pregnant women should use it with careful consideration, and lactating women need to weigh the pros and cons.

Older patients: For older patients, doctors may need to adjust the dose, making decisions based on kidney function and other factors.

10. Launch and price situation:

Avosidenib is already on the market in China, but it has not yet been included in medical insurance. The price of Avosidenib on the domestic market is very high, reaching tens of thousands of yuan. For specific prices, please consult the local hospital pharmacy. The price of the American original drug of Ivonib abroad is as high as hundreds of thousands. Currently, there are generic drugs of Ivonib on the market, mainly Laos generic drugs, which cost about 10,000 yuan, which is much cheaper in comparison, and the ingredients of the original drug and the generic drug are basically the same.