Synthetic route of Bosutinib

Bosutinib (Bosutinib) is a tyrosine kinase inhibitor commonly used to treat chronic myeloid leukemia. Its synthetic route involves multiple steps, the following is a simplified description:

First, the first step in the synthesis of bosutinib usually involves a substitution reaction of a starting material (usually a compound containing a carboxyl group) to introduce specific functional groups. This may involve reactions common in organic synthesis such as alkylation, olefination or arylation.

Next, after a series of reactions, the intermediate is converted into another intermediate containing a special structure. These reactions may include steps such as reduction, oxidation, substitution, and condensation. Among them, selective substitution of functional groups at specific positions is crucial to constructing the structure of the target molecule.

In the synthesis of bosutinib, a fusion cyclization reaction may be used to form the ring structure of the target molecule. This may involve using suitable reaction conditions and catalysts to ensure high yields and selectivity.

The ring structure was then further modified to introduce additional functional groups required in the bosutinib molecule. This may include amino acid substitutions, insertion of substituents, or other organic synthesis strategies.

Finally, through a series of meticulous steps, the target molecule of bosutinib is synthesized. At each step of the synthetic route, chemists need to carefully optimize reaction conditions, select appropriate catalysts, and solvents to ensure high yields and purity.

It should be noted that the specific synthetic route of bosutinib may vary depending on the manufacturer, patent restrictions, and innovation of the synthetic chemist. Therefore, detailed synthetic routes may require reference to relevant scientific literature or patent documents.

Bosutinib is not yet available in China, so patients cannot purchase it domestically and need to purchase it through overseas channels. There are original drugs and generic drugs of bosutinib abroad. The original drugs include the Turkish original drug and the European version of the original drug. The Turkish version of the original drug costs about 2,000 to 3,000 yuan, and the European version of the original drug costs about 30,000 yuan. In addition, there are cheaper generic drugs, which cost more than one thousand yuan, and the ingredients of the original drugs and generic drugs are basically the same.