What are the side effects of Lenvatinib?

In clinical studies of lenvatinib in various cancers, the most common adverse reactions include hypertension, diarrhea, appetite and weight loss, fatigue, nausea, proteinuria, stomatitis, vomiting, dysphonia (hoarseness), headache, and palmoplantar dysesthesia syndrome (PPE; rash and numbness of the palms and soles). When used in combination with medications, the most common adverse reactions include hypothyroidism, arthralgia, constipation, urinary tract infection, abdominal pain, weakness, anemia, hypomagnesemia, peripheral edema, cough, dyspnea, rash, and bleeding events.

The most common serious side effects of lenvatinib include kidney failure and damage; heart and blood circulation problems such as heart failure, blood clots in the arteries that lead to stroke or heart attack, bleeding in the brain, or swelling of the blood vessels from the mouth to the stomach, a syndrome called "posterior reversible encephalopathy syndrome" which is characterized by headache, confusion, visual discomfort, liver failure, hepatic encephalopathy (brain damage caused by liver failure), stroke, and heart attack. After lenvatinib was put on the market, adverse events such as pancreatitis, increased amylase, impaired wound healing, cholecystitis, nephrotic syndrome, arterial (including aortic) aneurysm, dissection and rupture also occurred.

Lenvatinib The original drug has been launched in China and has entered the scope of Class B medical insurance. The price of 4mg*30 tablets per box may be more than 3,000 yuan. Lenvatinib original drug currently on the market overseas, specifications 4mg*30 capsules, may cost more than 1,000 yuan per box (the price may fluctuate due to exchange rates). Lenvatinib generic drugs are also produced and marketed overseas. Their drug ingredients are basically the same as those of the original drugs sold domestically and abroad, but the price is cheaper. For example, the price of a box of 4mg*30 tablets produced by a Bangladesh pharmaceutical factory may be around RMB 800 (the price may fluctuate due to exchange rates).