Acalabrutinib Chinese instructions

1. Indications

Acotinib is a new generation of oral small molecule targeted drug, mainly suitable for the following diseases:

1.Chronic lymphocytic leukemia (CLL): For use in adult patients as part of first-line treatment or as an alternative treatment in cases of resistance or intolerance to other treatment options.

2.Small lymphocytic lymphoma (SLL): As part of first-line treatment in adult patients who are resistant to or intolerant to previous treatment regimens.

2. Mechanism of action

The main mechanism of action of acotinib is to selectively inhibit the activity of brutenib (BTK), thereby blocking the B cell receptor signaling pathway. BTK is a key protein in B cells, and its abnormal activation is related to a variety of malignant lesions of B cells. By interfering with this signaling pathway, acotinib can inhibit the growth and spread of cancer cells.

3. Pharmacology

1.Pharmacokinetics: Acotinib is rapidly absorbed in the body, reaches a high peak concentration, and has a moderate half-life, which helps maintain the therapeutic effect.

2.Pharmacodynamics: Acotinib produces a therapeutic effect on cancer cells by specifically inhibiting BTK activity and reducing B cell signaling.

4. Dosage and usage

1.Dosage form: Acotinib is an oral preparation, and each tablet contains a specified drug content.

2.Usage: Patients should take the tablet on an empty stomach or after and before meals according to the dosage recommended by the doctor every day. The tablet must be swallowed whole and avoid chewing or breaking.

5. Side Effects

Possible side effects of acotinib include but are not limited to:

1.Hypertension: Some patients may experience elevated blood pressure and require close monitoring.

2.Headache: Some patients have reported mild to moderate headaches during use, which are usually temporary.

6. Warnings and Precautions

1.Bleeding risk: Since acotinib may affect platelet function, patients should pay attention to observe whether abnormal bleeding occurs during use.

2.Cardiovascular risk: The risk of cardiovascular events may increase during the use of acotinib, especially in patients with existing cardiovascular disease.

7. Contraindications

Severe allergic reaction: Contraindicated in patients with severe allergic reaction to acotinib or any component of the formulation.

8. Drug interactions

Interactions with anticoagulant drugs: Acotinib may increase the anticoagulant effect of anticoagulant drugs and should be used with caution.

9. Medication for Special Populations

1.Pregnant and lactating women: Acotinib has certain risks to the fetus, and pregnant women should use it under the advice of a doctor.

2.Elderly patients: For elderly patients, dosage adjustments may be necessary to account for changes in renal function.

10. Listing and price situation:

Acotinib has been launched in China, but it has not yet been included in medical insurance. Since it has just been launched, it is still difficult for patients to purchase it domestically. They need to purchase acotinib through overseas channels. The cheaper ones abroad are mainly generic drugs, mainly Bangladeshi generic drugs. The price is around 6,000 to 7,000, and the ingredients of original drugs and generic drugs are basically the same.

When using acotinib, patients should conduct regular monitoring according to the doctor's recommendations to ensure the efficacy and safety of the drug. If adverse reactions or symptoms occur, patients should promptly inform their doctors so that appropriate adjustments and treatments can be made.