How to take Dacomitinib

Doctors will select patients for first-line treatment of metastatic non-small cell lung cancer with dacomitinib (Dacomitinib) based on the presence of EGFR exon 19 deletion or exon 21 L858R substitution mutation in the tumor specimen. The recommended dose of dacomitinib is 45 mg taken orally once daily until disease progression or unacceptable toxicity occurs, with or without food.

If a patient experiences adverse reactions while using dacomitinib, the doctor will adjust the drug dosage based on the severity of the condition. The first dose will be reduced to 30 mg orally once daily, and the second dose will be reduced to 15 mg orally once daily. Concomitant use of proton pump inhibitors (PPIs) should be avoided while taking dacomitinib. As an alternative to PPIs, use a locally acting antacid or, if using a histamine 2 (H2) receptor antagonist, give dacomitinib at least 6 hours before or at least 10 hours after taking the H2 receptor antagonist.

The original drug of dacomitinib has been launched in China and has entered the scope of Class B medical insurance. The price of the common specification 15mg*30 tablets per box may be more than 1,000 yuan; the European version of dacomitiniboriginal drug sold overseas, the specification 45mg*30 tablets may be more than 20,000 yuan per box (the price may fluctuate due to exchange rates). Currently, there are cheaper generic drugs of dacomitinib sold overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 45mg*30 tablets produced by a Lao pharmaceutical factory may be around a few hundred yuan per box (the price may fluctuate due to exchange rate effects).