How much does a box of Dacomitinib cost?

A trial approved by the U.S. Food and Drug Administration (FDA)Dacomitinib (Dacomitinib) has been confirmed as a first-line treatment for patients with metastatic non-small cell lung cancer (NSCLC) who have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R substitution mutations. Dacomitinib is available in tablets of 15, 30 and 45 mg.

Lung cancer is the leading cause of cancer death, with non-small cell lung cancer accounting for 85% of cancer cases. Among NSCLC cancer cases, approximately 75% of patients are diagnosed with metastatic and advanced disease at a late stage, with a survival rate of 5%. EGFR mutations account for more than 60% of non-small cell lung cancer cancer cases, and EGFR overexpression is associated with frequent lymph node metastasis and poor sensitivity to chemotherapy. Patients usually take the 45 mg tablet once daily, around the same time each day, and can be used as long as the patient benefits from it and the side effects are tolerable, but if certain side effects occur, the doctor may decide to reduce the dose or stop treatment.

The original drug of dacomitinib has been launched in China and has entered the scope of Class B medical insurance. The price of the common specification 15mg*30 tablets per box may be more than 1,000 yuan; the European version of dacomitiniboriginal drug sold overseas, the specification 45mg*30 tablets may be more than 20,000 yuan per box (the price may fluctuate due to exchange rates). Currently, cheaper generic drugs of dacomitinib are also sold overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 45mg*30 tablets produced by a Laos pharmaceutical factory may be around 800 yuan per box (the price may fluctuate due to exchange rate effects).