Can I stop taking Dacomitinib and how long should I take it again?

Dacomitinib (Dacomitinib) is used to treat non-small cell lung cancer that has spread (metastatic) with epidermal growth factor receptor (EGFR) exonexon 19 deletion or exon 21 L858R substitution mutation gene. Doctors will use tests to check for mutations before patients receive this drug. This drug is only available with a doctor's prescription.

As an irreversible, highly selective second-generation EGFR-TKIdacomitinib inhibits signals from all members of the human EGFR family. The ARCHER 1050 study showed that dacomitinib significantly improved progression-free survival (PFS) compared with gefitinib [14.7 vs. 9.2 months]. The time to discontinue dacomitinib should be determined by the physician based on the patient's specific circumstances. Dacomitinib is usually used long-term. While taking dacomitinib, you should take the medication regularly as directed by your doctor and do not stop or change the dose on your own. If you have any questions about stopping your medication or need to temporarily stop taking it, it's best to talk to your doctor. The correct time to stop taking medication and start taking it again can only be determined under the guidance of a doctor.

The original drug of dacomitinib has been launched in China and has entered the scope of Class B medical insurance. The price of the common specification 15mg*30 tablets per box may be more than 1,000 yuan; the European version of dacomitiniboriginal drug sold overseas, the specification 45mg*30 tablets may be more than 20,000 yuan per box (the price may fluctuate due to exchange rates). Currently, there are cheaper generic drugs of dacomitinib sold overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 45mg*30 tablets produced by a Lao pharmaceutical factory may be around a few hundred yuan per box (the price may fluctuate due to exchange rate effects).