Will Venetoclax be a drug included in medical insurance in 2023?

Venetoclax/Venetoclax (Venetoclax) is a targeted therapy drug, mainly used for Treatment of certain types of hematological malignancies, particularly B-cell lymphoma and chronic lymphocytic leukemia (CLL). The drug was developed by the US company AbbVie in cooperation with Genentech. It obtained emergency use authorization (EUA) in 2016 and has since been approved by many countries and regions.

Venetoclax/Venetoclax has been launched in China and has been included in medical insurance, and patients can purchase it domestically. Specifications: 100mg*14tablets and the price is around 5,000yuan. Please consult the local hospital pharmacy for specific prices. There are original drugs and generic drugs abroad. The Turkish version of Venetoclax/Venetoclaxoriginal drug on the market overseas, specification: 100mg*112 tablets, costs about 10,000 per box. Foreign generic drugs are relatively cheaper. For example, the generic drugs sold in Laos and Bangladesh are priced at about more than 4,000 yuan for 100mg*120 tablets. The ingredients of original drugs and generic drugs are basically the same.

The mechanism of action of venetoclax/venetoclax mainly involves the inhibition of B cell lymphoma/leukemia-2 (BCL-2) protein. BCL-2The protein is overexpressed in some hematological malignancies, making cancer cells more resistant to apoptosis (programmed cell death). Venetoclax/Venetoclax blocks this resistance mechanism by specifically binding and inhibiting BCL-2, thereby promoting cancer cells to enter the apoptosis process and helping to control the progression of the disease.

This drug is excellent in treatingCLL and related diseases. Particularly for patients whose disease has progressed despite other treatments, venetoclax provides an innovative treatment option. Its efficacy is not only reflected in the relief of symptoms, but also leads to complete pathological and clinical responses in some cases, bringing more lasting improvement to patients.

However, the use of venetoclax/venetoclax may also be associated with some side effects, such as anemia, thrombocytopenia, infection, etc. Therefore, during use, doctors usually need to monitor and adjust the treatment plan according to the patient's specific conditions.