The functions and efficacy of Selegiline Hydrochloride Tablets (Selegiline)

Selegiline hydrochloride tablets, in pill form, are used to treat the symptoms of Parkinson's disease. It is most commonly used as an adjunct to medications such as levodopa (L-DOPA), although it has been used as monotherapy off-label. The rationale for adding selegiline hydrochloride to levodopa is to reduce the required dose of levodopa and thereby reduce motor complications of levodopa therapy.

Selegiline hydrochloride delays the need for levodopa treatment from approximately 11 months to approximately 18 months after diagnosis. There is some evidence that selegiline hydrochloride is neuroprotective and may reduce the rate of disease progression, although this is controversial. The oral bioavailability of selegiline hydrochloride tablets is approximately 10% and is increased when ingested with a fatty meal because the molecule is fat-soluble. Selegiline Hydrochloride Tabletsand its metabolites are extensively bound to plasma proteins (binding rate94%) and are mainly metabolized in the intestine and liver; it and its metabolites are excreted in the urine. Compared with oral tablets, oral administration of selegiline hydrochloride results in a 5-fold increase in bioavailability, more reproducible blood concentrations and the production of fewer amphetamine metabolites.

Selegiline Hydrochloride TabletsThe original drug has been launched in China and has entered the scope of Class B medical insurance. The common price per box may be around around RMB 1,000. The price of Selegiline Hydrochloride Tabletsgeneric drugs currently sold overseas is cheaper, and its pharmaceutical ingredients are basically the same as those of the original drug. The price of 5mg*100 tablets per box may be several hundred RMB (the price may fluctuate due to the exchange rate). For more specific prices and drug information, please consult Yaode Medical Consultant.