What kind of medicine is Sotorasib?

Sotorasib (Sotorasib) is a new type of anti-cancer drug that belongs to the category of KRAS G12C inhibitors. The development of this type of drug is a major breakthrough in the field of tumor treatment, especially in patients with non-small cell lung cancer (NSCLC). Drugs against KRASgene G12C mutation have always been a problem that scientists are working hard to overcome.

The unique feature of sotorasiib is that it can directly act on the G12C mutation of the KRAS gene. KRASThe gene plays a key regulatory role in cells and is involved in cell growth and differentiation. However, when the KRAS gene mutates G12C, it loses its normal growth control function, causing abnormal cell growth and eventually the formation of cancer.

Sotorasiib directly affects the growth signaling pathway of cancer cells by specifically inhibiting the KRAS G12C mutation, thus blocking the development of tumors. This targeted treatment approach allowed sotorasiib to demonstrate significant efficacy in some patients with KRAS G12C mutated NSCLC.

Clinical trial results show that sotorasiib has a significant therapeutic effect in some KRAS G12C mutated NSCLC patients, bringing new treatment options to this patient group. Its development represents a breakthrough in the field of KRAS gene therapy, because in the past scientists have considered directly interfering with the KRAS gene to be a difficult task.

The original drug of sotorasibu has not yet been launched in China, so patients cannot purchase it domestically and need to purchase sotorasibu through overseas channels. The original version of sotorasibu in Hong Kong, China, has the specifications of 120mg*240 tablets and the price is 8The price of the European version of the original drug of the same specifications is around 40,000, which is relatively expensive. The cheaper ones are the generic drugs marketed abroad. For example, the price of generic drugs in Laos and Bangladesh is around two to three thousand yuan. The price is relatively cheap, and the ingredients of foreign generic drugs are basically the same as the original drugs.