Can Trelagliptin and Semaglutide be used together?

Trelagliptin (Trelagliptin) and semaglutide (Semaglutide) are two different types of drugs, but they are both members of the oral hypoglycemic drugs. Trelagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, while semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. There are currently no clear data indicating that trolagliptin and semaglutide can be used simultaneously. The two drugs have different pharmacological mechanisms of action and may present a risk of interaction.

Trelagliptin works by inhibiting the activity of DPP-4 enzyme. DPP-4 enzyme is an enzyme that breaks down glucagon-like peptide-1 and glucagon-like peptide-2 (GLP-2) in the body. Tretagliptin can increase the concentration and bioavailability of GLP-1. This increases the release of insulin and reduces the production of glucose, which helps lower blood sugar levels. The chemical structure of semaglutide is similar to natural GLP-1, and it can simulate the biological activity of GLP-1 in vivo. Promote insulin secretion by binding to insulin receptors. This helps increase the concentration of insulin in the blood, thereby increasing the uptake and utilization of glucose within cells. Therefore, patients are advised to seek the advice of their doctor or pharmacist before using these two drugs together.

The original drug of trotagliptin has not yet received relevant approval for marketing in China, so it cannot be covered by medical insurance. Currently, the price of trotagliptin original drug, specification 50mg*20 tablets per box, which is currently on the market overseas, may be around RMB 1,000 (the price may fluctuate due to exchange rates). There are also generic Trelagliptin drugs produced in other countries, and their pharmaceutical ingredients are basically the same as those of the original drug. For example, the price of 100mg*21 tablets produced by a Bangladesh pharmaceutical factory may be several hundred yuan per box (the price may fluctuate due to exchange rates). For more drug information and specific prices, please consult Yaode Medical Consultant.