Which one is better, Trelagliptin or Saxagliptin?

Trelagliptin (Trelagliptin) and Saxagliptin (Saxagliptin) are both diabetes treatment drugs and are dipeptidyl peptidase inhibitors (DPP-4 inhibitors). Their mechanisms of action are similar, and their effects and side effects are also similar. However, tretagliptin may be more effective than saxagliptin in certain circumstances, and attention should be paid to abnormal liver function. When using drugs, you need to choose the appropriate drug based on your doctor's advice and individual circumstances.

Tretagliptin and saxagliptin both belong toDPP-4 inhibitors. By inhibiting the activity of DPP-4 enzyme, they increase the levels of glucagon-like peptide (GLP-1) and glucose-dependent insulin-releasing polypeptide (GIP), thereby promoting insulin secretion and lowering blood sugar levels. Both trotagliptin and saxagliptin can effectively lower blood sugar levels, reduce blood sugar fluctuations, and reduce the risk of hypoglycemia. However, trotagliptin may be more effective than saxagliptin in certain circumstances, especially when used in combination with insulin. The side effects of trotagliptin and saxagliptin mainly include minor discomforts such as headache, nausea, and diarrhea. However, liver function abnormalities may occur in some patients with tretagliptin and less commonly with saxagliptin.

The original drug of trotagliptin has not yet received relevant approval for marketing in China, so it cannot be covered by medical insurance. Currently, the price of trotagliptin original drug, specification 50mg*20 tablets per box, which is currently on the market overseas, may be around RMB 1,000 (the price may fluctuate due to exchange rates). There are also generic Trelagliptin drugs produced in other countries, and their pharmaceutical ingredients are basically the same as those of the original drug. For example, the price of 100mg*21 tablets produced by a Bangladesh pharmaceutical factory may be several hundred yuan per box (the price may fluctuate due to exchange rates). For more drug information and specific prices, please consult Yaode Medical Consultant.