The Difference Between Ologliptin and Trelagliptin

Omarigliptin (Omarigliptin) and Trelagliptin (Trelagliptin) are both drugs used to treat type 2 diabetes. They are glucagon-like peptide 1 (GLP-1) analogs. By binding to the corresponding receptors, they promote the release of insulin while inhibiting glucagon levels, thereby lowering blood sugar.

Ologliptin improves insulin sensitivity and lowers blood glucose levels by increasing the levels of endogenous glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Tretagliptin inhibits cell proliferation by inhibiting cell cycle progression, thereby improving glycemic control. Ologliptin is generally indicated for use in adults with type 2 diabetes, especially those who have poor glycemic control with metformin alone. Trelagliptin is suitable for adults with type 2 diabetes who have poor blood sugar control when combined with metformin. When using drugs, patients need to choose the drug that suits them according to the doctor's advice, and pay attention to factors such as diet and exercise to maintain the stability of blood sugar.

The original drug of trotagliptin has not yet received relevant approval for marketing in China, so it cannot be covered by medical insurance. Currently, the price of trotagliptin original drug, specification 50mg*20 tablets per box, which is currently on the market overseas, may be around RMB 1,000 (the price may fluctuate due to exchange rates). There are also generic Trelagliptin drugs produced in other countries, and their pharmaceutical ingredients are basically the same as those of the original drug. For example, the price of 100mg*21 tablets produced by a Bangladesh pharmaceutical factory may be several hundred yuan per box (the price may fluctuate due to exchange rates). For more drug information and specific prices, please consult Yaode Medical Consultant.