The difference between Asciminib and Orebatinib

Asciminib (Asciminib) and olverembatinib (Olverembatinib) are both targeted drugs, but there are some differences in their mechanisms of action, applicable diseases, and applicable groups. Patients need to conduct corresponding examinations and evaluations before using these drugs, and follow the doctor's recommendations.

Aximinib is an ABL/BCR-ABL1 tyrosine kinase inhibitor. Aceminib inhibits the ABL1 kinase activity of the BCR-ABL1 fusion protein by binding to the myristoyl pocket of ABL. Aceminib showed activity against wild-type BCR-ABL1 and several mutant forms of the kinase, including the T315I mutation, in studies conducted in vitro or in animal models of chronic myelogenous leukemia. Aceminib is indicated for the treatment of adult patients with Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+CML) in the chronic phase who have been previously treated with ≥2 tyrosine kinase inhibitors. It is also indicated for the treatment of adult patients with Ph+CML with the T315I mutation.

Orebatinib is an oral third-generation BCR-ABL1 tyrosine kinase inhibitor (TKI). It is an ATP-binding site inhibitor of wild-type BCR-ABL1 kinase and broad-spectrum BCR-ABL1 mutants (including mutant T315I). It is resistant to all first- and second-generation TKIs. It is currently approved for the first time in China for the treatment of adult patients with TKI-resistant chronic myelogenous leukemia (CML-CP) or accelerated phase chronic myeloid leukemia (CML-AP) carrying the T315I mutation.

The original drug of Asiminib has not yet been launched in China, so it cannot be included in medical insurance. The original drug of Asiminib currently sold overseas is very expensive. Generic drugs of Asiminil are also produced and marketed overseas, and their drug ingredients are basically the same as those of the original drug. For example, the price of 40mg*60 tablets produced by a Laos pharmaceutical factory may be more than 4,000 yuan per box (the price may fluctuate due to exchange rate effects), and the price is relatively cheap. For more drug information and specific prices, please consult Yaode’s medical consultant.