How much does Tepotinib cost in 2023

Tepotinib is an oral methionine(MET)inhibitor indicated for the treatment of patients with mesenchymal-epithelial transition< /span>(MET)Exon14 skipping alteration metastatic non-small cell lung cancer (NSCLC) patients. This indication received accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and characterization of clinical benefit in confirmatory trials.

Tepotinib is indicated for adult patients whose tumors have an abnormal mesenchymal-to-epithelial transition (MET) gene found by a U.S. Food and Drug Administration (FDA)-approved test. Patients may take tepotinib once daily with food until disease progression or unacceptable toxicity occurs. Patients taking tepotinib should be warned of an increased risk of serious or fatal interstitial lung disease/pneumonitis, the potential risk of hepatotoxicity and embryo-fetal toxicity and the need to use effective contraception during and shortly after treatment. Common adverse reactions include edema, fatigue, nausea, diarrhea, musculoskeletal pain, and dyspnea.

The original drug Tepotinib is already on the market in China, but it is not yet eligible for medical insurance. Tepotinib Original drug currently marketed overseas is relatively expensive, and the price of each box of 225mg*30 tablets may be around RMB 80,000 (the price may fluctuate due to exchange rates). There are already generic Tepotinib drugs produced in other countries. The ingredients of these generic drugs are basically the same as those of the original drug, but the price is relatively cheap. For example, the price of 225mg*60 tablets produced by a Laos pharmaceutical factory may be more than 8,000 yuan per box (the price may fluctuate due to exchange rates).