Instructions for Pimitespib

1. Name: Pimitespib, Jeselhy

2. Indications:

Pimitespib (Pimitespib) is commonly used to treat gastrointestinal stromal tumors (GIST) that have progressed after chemotherapy.

3. Usage and dosage:

1. Recommended dose: Generally speaking, for adults, take 4 tablets (160 mg of active ingredient) pimetibi on an empty stomach for 5 consecutive days once a day, and then rest for 2 days. Repeat this dosing regimen. Depending on the patient's condition, the dose may be reduced. Follow instructions strictly. Avoid taking this medicine 1 hour before to 2 hours after meals.

If a dose is missed, skip the missed dose and continue with the regular dosing schedule. If you accidentally take more than the prescribed dose, consult your doctor or pharmacist. Do not stop taking this medicine unless directed by your doctor to do so.

4. Adverse reactions:

The most commonly reported adverse reactions of pimetibib include diarrhea, eye symptoms, bleeding, taste changes, loss of appetite, nausea/vomiting, and malaise.

5. Storage:

It is recommended that pimoteb be kept out of the reach of children. Store away from direct sunlight, high temperature and moisture. Discard remaining portion. Don't store them. Do not give this medicine to anyone.

6. Special groups:

Women who may become pregnant or men whose partners may become pregnant should avoid becoming pregnant while taking this medication and for some time after stopping this medication.

7. Mechanism of action:

Pimetibib is believed to inhibit the formation of higher-order structures of client proteins by HSP90, thereby reducing the expression levels of proteins related to tumor growth, inducing apoptosis, etc., thereby exhibiting tumor growth inhibition. In vitro, pimetibi showed a growth inhibitory effect on theGIST-T1 cell line derived from human gastrointestinal stromal tumors; in vivo, pimetibib showed a tumor growth inhibitory effect in nude mice subcutaneously transplanted with theGIST-T1 cell line.

Pimetibi is not marketed in China, and it has been on the market overseas for a short time, and there is little information about its price and other related information.