How to take Pimitespib

PimitespibPimitespib is a drug used to treat gastrointestinal stromal tumors. Discovered and developed by Dabao Pharmaceutical Company, Trade nameJeselhy, The mechanism of action of pimetibi involves inhibiting heat shock protein90 (Hsp90). In June 2022, it was approved in Japan for gastrointestinal stromal tumors (GIST) that have progressed after chemotherapy. Pimetibi can inhibit the function of HSP90 and reduce various proteins involved in cancer cell survival and proliferation, thus showing anti-tumor effects.

During a patient's treatment, doctors may use computed tomography or magnetic resonance imaging scans to evaluate tumors at baseline, every 3 weeks for the first 6 weeks, then every 6 to 24 weeks, and every 8 weeks thereafter. During the double-blind period, BCRR and investigator assessments were performed at each assessment point.

Generally speaking, for adult patients, take 4 tablets (160 mg of active ingredient) pimetibi once daily on an empty stomach for 5 consecutive days, followed by a 2-day break. Repeat this dosing regimen. Depending on the patient's condition, the dose may be reduced. Follow instructions strictly. Avoid taking this medicine 1 hour before to 2 hours after meals. If a dose is missed, skip the missed dose and continue with the regular dosing schedule. If you accidentally take more than the prescribed dose, consult your doctor or pharmacist. Do not stop taking this medicine unless directed by your doctor to do so. Women who may become pregnant or men whose partners may become pregnant should avoid becoming pregnant while taking this medication and for some time after stopping this medication.

Pimetibi is not marketed in China, and it has been on the market overseas for a short time, and there is little information about its price and other related information.