Brigatinib/Brigatinib (Brigatinib) combined with cetuximab

Brigatinib/Brigatinib and Cetuximab (Cetuxiab) are two different drugs. Brigatinib is a tyrosine kinase inhibitor that targets ALK and is commonly used to treat non-small cell lung cancer with ALK-positive mutations . Cetuximab is a humanized monoclonal antibody directed against EGFR and is commonly used to treat head and neck squamous cell carcinoma and metastatic colorectal cancer with wild-type RAS gene and EGFR expression.

Among the 5 EGFR 19del-T790M-cis-C797S mutation-positive patients who received brigatinib and cetuximab combination therapy, 3 patients achieved partial response and 2 patients had stable disease, resulting in an overall objective response rate of 60% and a disease control rate of 100%. Among 10 patients who were positive for EGFR 19del or L858R-T790M-cis-C797S mutations and received chemotherapy, only 1 patient achieved partial response, 5 patients had stable disease, and 4 patients did not benefit from chemotherapy, resulting in an overall objective response rate and disease control rate of 10% and 60%, respectively. Median progression-free survival was 14 months for patients who received the combination targeted therapy and 3 months for those who received chemotherapy. Based on this finding, the combination of targeted therapy brigatinib and cetuximab may be beneficial and may be an effective treatment strategy to improve survival outcomes in patients with EGFR T790M-cis-C797S-mediated resistance to osimertinib.

This original drug is marketed in China under the name brigatinib, and has entered the scope of Class B medical insurance. Specifications The price of 30mg*14 tablets*2 tablets per box may be around 8,000 yuan, which is relatively expensive. Currently, there are relatively cheap generic brigatinib drugs on the market overseas. Their drug ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of a box of 90mg*30 tablets produced by a Bangladesh pharmaceutical factory is around 2,000 yuan (the price may fluctuate due to exchange rates).