What are the side effects of trametinib?

Trametinib is an oral targeted drug indicated for the adjuvant treatment of BRAF V600E or V600K mutation-positive unresectable or metastatic melanoma; BRAF V600E or V600K mutation-positive melanoma; BRAF V600E mutation-positive metastatic non-small cell lung cancer; BRAF V600E mutation-positive locally advanced or metastatic anaplastic thyroid cancer; BRAF V600E mutation-positive unresectable or metastatic solid tumors; BRAF V600E mutation-positive low-grade gliomas.

What are the side effects of trametinib?
For monotherapy side effects included increased AST (60%), rash (57%), hyperglycemia (50%), increased ALT (39%), leukopenia (38%), anemia (46%), neutropenia (44%), diarrhea (43%), hypoalbuminemia (42%), hyperphosphatemia (37%), hyperkeratosis (37%), headache (32%), lymphedema (32%), fever (28%), arthralgia (27%), papilloma (27%), Increased alkaline phosphatase (24%), alopecia (22%), palmar-plantar dysesthesia syndrome (20%), acneiform dermatitis (19%), stomatitis (15%), hypertension (15%), abdominal pain (13%), bleeding (13%), back pain (12%), cough (12%), myalgia (11%), dry skin (11%), constipation (11%).
For BRAF Side effects in patients with V600E or V600K mutation-positive melanoma include elevated AST (57%), hyperglycemia (60-63%), pyrexia (54-63%), fatigue (59%), neutropenia (46-47%), trough Elevated alanine aminotransferase (48%), hypoalbuminemia (25-48%), anemia (25-43%), hypophosphatemia (38-42%), nausea (35-40%), headache (30-39%), increased alkaline phosphatase (38%) , rash (32-37%), chills (31-37%), diarrhea (31-33%), lymphopenia (26-32%), vomiting (27-28%), joint pain (25-28%), hypertension (26%), hyponatremia ( 25%), peripheral edema (21%), thrombocytopenia (21%), cough (20%), myalgia (15-20%), abdominal pain (18%), bleeding (18%), constipation (13%), nasopharyngitis (12%), dizziness (11%), etc.
For advanced BRAF V600E-mutation-positive tumors (children) side effects include fever (75%), rash (73%), hyperglycemia (65%), decreased hemoglobin (60%), increased AST (55%), vomiting (52%), neutrophilia Granulocytopenia (49%), fatigue (48%), dry skin (48%), hypoalbuminemia (48%), cough (44%), diarrhea (42%), acneiform dermatitis (40%), hypocalcemia (40%), glutamine Increased transaminases (40%), decreased phosphate (38%), headache (35%), abdominal pain (33%), nausea (33%), bleeding (33%), decreased magnesium (33%), increased alkaline phosphatase (28%), neutral Granulocytopenia, grade 3 or 4 (28%), hypernatremia (27%), constipation (23%), paronychia (23%), hypokalemia (21%), increased total bilirubin (21%), fever, grade 3 or 4 (17%), etc.
For advanced BRAF V600E-mutation-positive tumors (adults) side effects include hyperglycemia (61%), pyrexia (55%), increased alkaline phosphatase (51%), increased AST (51%), fatigue (50%), decreased hemoglobin (44%), nausea (40%), rash (40%), increased alanine aminotransferase (39%), sodium Reduction (35%), chills (30%), headache (30%), bleeding (29%), cough (29%), constipation (27%), vomiting (27%), diarrhea (26%), myalgia (24%), decreased magnesium content (24%), joint pain (23%), peripheral edema (22%), increased creatinine (21%), etc. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.