Osimertinib latest price in 2023

Osimertinib (Osimertinib) is indicated as a monotherapy for the adjuvant treatment after complete tumor resection in adult patients with IB-IIIA non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations; it can also be used as a first-line treatment for adult patients with locally advanced or metastatic NSCLC with activating EGFR mutations; also for the first-line treatment of locally advanced or metastatic EGFR Treatment of adult patients with T790M mutation-positive non-small cell lung cancer.

In vitro studies have shown that osimertinib has high potency and inhibitory activity against EGFR in a range of clinically relevantEGFR-sensitizing mutant and T790M mutant NSCLC cell lines (apparent IC50 for phosphorylated EGFR ranging from 6 nM to 54 nM). This resulted in inhibition of cell growth with a significant reduction in activity against EGFR in the wild-type cell line (apparent IC50 against phosphorylated EGFR from 480 nM to 1.8 μM). In vivo oral administration of osimertinib resulted in tumor shrinkage in EGFRm and T790M NSCLC xenografts and transgenic mouse lung tumor models.

OsimertinibThe original drug has been launched in China and has been covered by medical insurance. The price of 80mg*30 tablets per box may be around 5,000 yuan, which is relatively expensive. Currently available overseas Osimertinib generics, such as the specifications produced by Bangladesh Pharmaceutical FactoryThe price of each box of 80mg*30 tablets may be more than 800 yuan (the price may fluctuate due to exchange rate effects), which is relatively cheap. Osimertinib generics have basically the same pharmaceutical ingredients as the original drugs sold domestically and abroad. For more drug information and specific prices, please consult Yaode Medical Consultant.