Lorlatinib/lorlatinib usage and dosage

Lorlatinib/Lorlatinib is a third-generation targeted drug, applicable to patients with metastatic non-small cell lung cancer (NSCLC) , whose tumor tested positive for anaplastic lymphoma kinase (ALK) by an FDA-approved test. In the treatment of brain metastases, relevant trials show that the objective response rate (ORR) of lorlatinib can still reach 31%, and the effect of lorlatinib is obvious.

How to take lorlatinib and what dosage to use. The recommended dose of lorlatinib is 100 mg once daily, with or without food, until disease progression or unacceptable toxicity occurs. For dose adjustments in patients experiencing adverse reactions, first dose reduction to 75mg once daily, second dose reduction to 50mg once daily, intolerable 50mg once daily:Permanent discontinuation. For CNS effects, patients with grade 1:Continue the same dose or stop the dose until return to baseline; Patients with grade pan>2 or grade 3:stop administration until< Grade 1, resume after dose reduction, Grade 4 patients:permanent discontinuation. Avoid concomitant use with strong CYP3A4 inhibitors and fluconazole, and if use is unavoidable, reduce starting dose to 75mg/ days, if dose is reduced to 75mg/days, and if a strongCYP3Ainhibitor is started, reduce the dose to 50 mg/days, if a strongCYP3Ainhibitor is discontinued, reduce the dose(StrongCYP3A inhibitorsAfter 3 plasma half-lives)Increase to the dose before starting the strong inhibitor.

When taking Swallow the tablet whole without crushing, chewing or breaking it, Take the tablet at the same time every day with or without food, Do not use crushed or broken tablets. Ifa patientvomits shortly after takinglorlatinib, do not take additional doses. Wait until your next scheduled dose before taking your medication. When storing keep at room temperature, away from moisture and heat. Do notchange your dose or stop takinglorlatinib without your doctor's advice. Generic lorlatinib has been launched in Laos and Bangladesh, with prices ranging from 3 to 5 thousand per box. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.