Can I stop taking Upadacitinib once every seven days?

Upadacitinib (Upadacitinib) usually needs to be used long-term. If the patient has taken upadatinib for seven days as recommended by the doctor and the condition has been controlled, he or she may consider consulting the doctor and considering discontinuing the drug. However, before stopping the medication, you must consult your doctor to ensure that your body can adapt to stopping the medication. Your doctor may recommend that you gradually reduce your dose or use other medications to help you gradually stop taking upadacitinib.

Plasma exposure of upadatinib is dose-proportional across the therapeutic dose range. After healthy subjects took a single dose of upadatinib 15mg, 30mg and 45mg under fasting conditions, the average Cmax was 31.6ng/mL, 71.8ng/mL and 90.7ng/mL respectively, and the average AUCinf was 265ng*h/mL, 543ng*h/mL and 752ng*h/mL respectively. Following once-daily dosing, steady-state plasma concentrations are achieved within 4 days with minimal accumulation. Upadatinib pharmacokinetics are comparable between patients with rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, and nonradiographic axial spondyloarthritis.

The original drug Upatinib has been launched in China, and has subsequently entered the scope of Class B medical insurance. Only eligible patients can be reimbursed. Specifications The price of each box of 15mg*28 tablets may be around RMB 3,000. The European version of the original drug sold overseas is priced at more than 20,000 yuan for 15mg*30 tablets (the price may fluctuate due to exchange rates), which is expensive. Cheaper upadatinib generic drugs are also sold overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 15mg*30 tablets produced by Bangladesh pharmaceutical factory is around 900 yuan (the price may fluctuate due to the exchange rate).