How long does a course of Upadacitinib last?

The duration of a course of Upadacitinib (Upadacitinib) varies between individuals, and the specific duration depends on the patient's condition, age, weight and other factors. Generally speaking, upadatinib needs to be taken continuously for a period of time until the condition is controlled or symptoms are significantly improved. Do not stop taking or skip a dose of upadacitin unless directed by your doctor.

Upadatinib is administered as an extended-release formulation and was administered at doses of 15 mg and 30 mg once daily (QD) in Phase 3 studies in rheumatoid arthritis. The pharmacokinetic profile of upadatinib is biexponential, with a harmonic mean terminal half-life of 9 to 14 hours and a median time to maximum plasma concentration of 2 to 4 hours after dosing. No significant accumulation occurred after multiple once-daily administration of upadatinib extended-release formulations of 15 mg and 30 mg, with steady state reached on day 4. Upadatinib is used to treat chronic inflammation but does not completely cure it. Stopping or interrupting upadacitinib therapy may cause a patient's disease to worsen, so it is important to continue taking the drug even if the patient feels better.

The original drug Upatinib has been launched in China, and has subsequently entered the scope of Class B medical insurance. Only eligible patients can be reimbursed. Specifications The price of each box of 15mg*28 tablets may be around RMB 3,000. The European version of the original drug sold overseas is priced at more than 20,000 yuan for 15mg*30 tablets (the price may fluctuate due to exchange rates), which is expensive. Cheaper upadatinib generic drugs are also sold overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 15mg*30 tablets produced by Bangladesh pharmaceutical factory is around 900 yuan (the price may fluctuate due to the exchange rate).