What does Pemigatinib tablets do?

Pemigatinib (Pemigatinib) is a small molecule tyrosine kinase inhibitor of FGFR1, FGFR2 and FGFR3. Pemetinib inhibits FGFR phosphorylation and signaling and reduces cell viability in cell lines expressing altered FGFR genes, including point mutations, amplifications, fusions, or rearrangements. These genetic changes in the FGFR gene lead to the activation of FGFR signaling that supports malignant cell proliferation and survival.

Cancer cell lines with activating molecular changes inFGFR1, FGFR2 and FGFR3 are more sensitive to growth inhibition by pemetanide than cancer cell lines or normal cells without FGFR dependence (IC50>1500nM).IC50 values are mostly in the range of 3-50nM. Pemetinib is not chemotherapy; it is a targeted treatment for cholangiocarcinoma, which means it may help stop the spread of the cancer by interfering with specific molecular targets on cancer cells.

The original drug Pemetinib has been launched in China. Due to its short time on the market, it has not yet entered the scope of medical insurance. The price of each box of 9mg*14 tablets may be around 50,000 yuan, which is expensive. The original drug Pemetinib currently on the market overseas, with a specification of 13.5mg*14 tablets, may cost around RMB 70,000 per box (the price may fluctuate due to exchange rates). There are also generic pemetinib drugs produced in other countries overseas, and their drug ingredients are basically the same as those of the original drugs sold abroad. For example, the price of 4.5mg*14 tablets per box produced by a Laos pharmaceutical factory may be around 1,000 yuan (the price may fluctuate due to exchange rates).