Can I take Alpelisib while pregnant?

During pregnancy, especially in the early stages of pregnancy, the use of medications requires extreme caution because some medications may have adverse effects on the fetus. There is currently insufficient research data on the use of Alpelisib during pregnancy, so there may be certain risks in using Alpelisib during pregnancy.

Apelix is an inhibitor targetingPI3Kα and is used to treat breast cancer. Due to the particularity of its mechanism of action, as well as the metabolism and excretion of the drug in the human body, there is currently limited understanding of its safety in pregnant women and its impact on the fetus. In animal experiments, Apelvis may have adverse effects on the embryo during pregnancy, but these results may not necessarily be directly generalized to humans.

Typically, if a patient is pregnant or planning to become pregnant, a doctor will perform a detailed evaluation before considering the use of Apelvis or other medications. The doctor will weigh the potential benefits and potential risks of the drug and discuss it with the patient to develop the most appropriate treatment plan. During this process, doctors may consider alternative treatment options or delay medication to ensure the safety of the mother and fetus.

Apelis has not yet been launched in China, so it is not included in medical insurance. Therefore, patients cannot purchase it domestically and need to purchase Apelis through overseas channels. In foreign countries, the original Apelvis drug is mainly used. There are European and Indian versions of the original drug on the market. The price of the European version of the original drug is as high as tens of thousands of yuan. Relatively speaking, the price of the Indian version of the original drug is around four to five thousand yuan. The price is still relatively cheap. Moreover, the ingredients and efficacy of the European and Indian original drugs are consistent.