What are the contraindications for taking Crizotinib?

Patients when taking crizotinib ( Crizotinib) need to follow their doctor's recommendations and pay attention to drug interactions and adverse reactions to ensure safe and effective treatment. Long-term use of drugs may cause side effects, so regular physical examinations and evaluations are required, and the dosage and time of medication need to be adjusted according to the doctor's recommendations. There are currently some taboos that may require special attention.

First of all, it is contraindicated in patients who are allergic to crizotinib or any of its excipients. Secondly, while taking crizotinib, you should avoid taking certain drugs at the same time, such as strong CYP3A4 inhibitors, CYP3A4 inducers and CYP2D6 inhibitors, as this may affect the metabolism and efficacy of crizotinib. In addition, crizotinib may cause adverse reactions such as QT interval prolongation and arrhythmia, so regular electrocardiogram examinations are required. Finally, while taking crizotinib, patients should avoid exposure to high-risk environments, such as driving or operating machinery, because symptoms such as dizziness and vertigo may occur.

The original drug Crizotinib has been launched in China and is covered by medical insurance, but it is only reimbursed for patients who meet the indications. The price per box may be around RMB 15,000. The price of the original Turkish version of Crizotinib sold overseas may be more than RMB 10,000 per box (the price may fluctuate due to exchange rates), which is expensive. There are also cheaper generic crizotinib drugs available overseas. The ingredients are basically similar to those of the original drugs sold domestically and abroad. For example, the price of 250mg*60 tablets produced by a Bangladesh pharmaceutical factory may be more than 2,000 yuan per box (the price may fluctuate due to exchange rates).