Crizotinib side effects

Crizotinib is an antineoplastic drug that is an inhibitor of multi-receptor tyrosine kinases including anaplastic lymphoma kinase(ALK) and c-rosoncogene -1 (ROS-1). Crizotinib in patients with metastatic non-small cell lung cancer (NSCLC) whose tumors test positive for anaplastic lymphoma kinase (ALK) or ROS1 on an FDA-approved test. It is used for children and young patients aged 1 and above who have relapsed or refractory systemic anaplastic large cell lymphoma (ALCL) and are ALK positive. For use in adult and pediatric patients 1 year and older with ALK-positive unresectable, recurrent, or refractory inflammatory myofibroblastic tumor (IMT). What are the side effects of crizotinib?

ALK or ROS1positive metastatic non-small cell lung cancer patients include visual impairment (≥25%), nausea (≥25%), diarrhea (≥25%), vomiting (≥25%), edema (≥ 25%), Constipation (≥25%), Elevated transaminase (≥25%), Fatigue (≥25%), Decreased appetite< /span> (≥25%), Upper respiratory tract infection (≥25%), Dizziness (≥25%), Neuropathy (≥25%).

Patients with ALKpositive metastatic non-small cell lung cancer include elevated alanine aminotransferase(76-79%), visual impairment(60-71%), ASTelevated(61-66%), diarrhea< /span>(60-61%), nausea(55-56%), neutropenia(49-52%), lymphopenia(48-51%), edema(31-49%), vomiting(46-47%), Constipation (42-43%), Upper respiratory tract infection (26-32%), Hypophosphatemia (28-32%), Low appetite Decline(27-30%), fatigue(27-29%), abdominal pain(26%), dysgeusia(26%), headache(22%), dizziness(18-22%), neuropathy(19-21%), fever(19%), hypokalemia(18 %), pain in limbs (16%), bradycardia (5-14%), dyspepsia (8-14%), rash (9-11%).

Patients with ALCL include neutropenia (100%), increased serum creatinine (100%), diarrhea (92%), vomiting (92%), increased alanine aminotransferase (81%), Nausea(77%), Elevated aspartate aminotransferase(65%), Visual disturbance(65%), Hypocalcemia(62%), Lymphopenia(58%), Headache(58%), musculoskeletal pain(58%), hypoalbuminemia(54%), anemia(54%), abdominal pain(50%), stomatitis(46%), hyperemia Diabetes(46%), Hypomagnesemia(46%), Fatigue(46%), Decreased appetite(42%), Thrombocytopenia(38%), Fever(38%), Hypoglycemia(35%), Pruritus(35%), Cough(35%), Hypokalemia(31%), Constipation(31%), Upper respiratory tract infection(31%), Hypertension(31%), Hypermagnesemia(27%), edema(27%), chills(27%), hyperkalemia(23%), dysgeusia(23% ), Dizziness(23%), Skin rash(23%), Allergic rhinitis(23%), Bradycardia(19%), Hypotension(19%), Increased alkaline phosphatase(19%), hypernatremia(19%), hyponatremia(12%), hyperuricemia(12%), hypophosphatemia(12%), peripheral neuropathy(12%). Approximate retail price of the second pharmaceutical manufacturer in Laos with the same specifications2600yuan, retail price of pharmaceutical manufacturers in Laos and ASEAN200mg60tablets51 00yuan, 250mg60 tablets5800yuan. The price of 250 mg 60 tablets of Laos Element Pharmaceuticals is around 2,600 yuan, the retail price of Beacon Pharmaceuticals in Bangladesh is around 3,900 yuan, and the retail price of Yaopin International in Bangladesh is around 2,700 yuan. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.