What is the difference between domestic and imported drugs of dasatinib?

Dasatinib(Dasatinib)is a very effective BCR-ABL inhibitor and is BC R-ABLdrives the diseases chronic myeloid leukemia(CML)and Philadelphia chromosome-positive acute lymphoblastic leukemia(Ph+ An effective treatment for ALL) characterized by a constitutively active tyrosine kinaseBCR-ABL. DasatinibIndicated for the treatment of:1.Newly diagnosed Philadelphia chromosome-positive (Ph+)Chronic myelogenous leukemia(CML)Adults in chronic phase. 2.Adults with chronic, accelerated, or myeloid or lymphoblastic phase Ph+ CML who are resistant or intolerant to prior treatment (including imatinib). 3.Adults with Philadelphia chromosome-positive acute lymphoblastic leukemia(Ph+ ALL) who are resistant or intolerant to previous treatments. 4.Chronic phasePh+ CMLChildren 1 years old and above. 5.Children 1 years old and above who are newly diagnosed with Ph+ ALL and receive chemotherapy. Currently, there are two types of domestic drugs and imported drugs on the domestic market. What is the difference between the two?

1.Manufacturers are different. The imported drugs are developed and produced by Bristol-Myers Squibb, and the domestic drugs are produced by Chia Tai Tianqing Pharmaceutical Co., Ltd.

2.The prices are different. The retail price of imported medicines in pharmacies is about 20mg 60 tablets 3900 yuan, and the retail price of domestic medicines in pharmacies is about 50mg 7 tablets 290 yuan.

3.Drug quality. The dosage specifications of the active ingredients of imported drugs are the same as those of domestic drugs. Imported drugs have undergone strict approval and quality control, and the quality control is high.

The most common adverse reactions (≥15%) in patients receiving dasatinib monotherapy included myelosuppression, fluid retention events, diarrhea, headache, rash, bleeding, dyspnea, fatigue, nausea, and musculoskeletal pain. The most common adverse reactions in pediatric patients receiving dasatinib combination chemotherapy (≥30%) include mucositis, febrile neutropenia, pyrexia, diarrhea, nausea, vomiting, musculoskeletal pain, abdominal pain, cough, headache, rash, fatigue, constipation, cardiac arrest, Arrhythmia, hypertension, edema, infection(bacteria, viruses and fungi), hypotension, decreased appetite, hypersensitivity, dyspnea, epistaxis, peripheral neuropathy and altered state of consciousness. There are generic drugs overseas, produced in India and Bangladesh, and each box costs about four to five hundred. For specific prices, you can consult domestic regular overseas pharmaceutical consulting agencies. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.

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